Principal Investigator: Prof. Dr. Raúl Bonne Hernández

Institution: Departamento de Ciências Exatas e da Terra. Instituto de Ciências Ambientais, Químicas e Farmacêuticas/ICAQF/UNIFESP. Universidade Federal de São Paulo.

 

Brazil is one of the main producers of manganese and aluminum, which are neurotoxic during the development and associates with some illnesses of the aging (Parkinson, Alzheimer and Amyotrophic Lateral Sclerosis), with elevated costs for public health. In Brazil the national prevalence of Alzheimer can arrive until 63% of the total of cases of dementia and 4% of the population with age above of 50 years must suffer of Parkinson in year 2030. At today, the explanations to the development of the above-mentioned illnesses and the neurotoxicity of these metals are unclear, where the chemical speciation and the potential interaction among metal species have been neglected reiteratively. Thus, this project intends to study the importance of aluminum and manganese speciation and its associations for its neurotoxicological mechanisms and its implication on some neurodegenerative diseases. This project will contribute for the clarification of the respective studies of environmental and neurotoxicological risk assessment of metals. This is will be a basic, applied and explicative research.

 

FAPESP Financing: 11/2011-4

 

Development of Filtering Devices for purifying of water projected for human consumption